If you are using a USB DAC then the Argon40 case for the RPI 4:
Argon40 Argon ONE V2 Case for Raspberry Pi 4 Raspberry Pi Portal in Asia
yes that could be a problem.
Yes … I see a problem with my suggestion. There seem to be a few power off options out there. Good luck with your search.
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maybe a bit of judicious soldering to change usb plugs?
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