Clicking with USB output

I’ve installed Volumio on my RPi (B). It’s running fine, but I get a regular clicking using the USB output (nothing out of the analogue 3.5mm). I’m using a NI Audio 4 DJ interface. It is a lot more regular over AirPlay, but still slightly apparent when playing from a local USB drive.

I’ve seen a couple of threads about a similar problem but haven’t found a solution. Does anyone have any ideas? Thanks.

Any help would be very useful. Thanks.